Annotation of Chorionic Villi in Products of Conception Using Combined Manual and Automated Techniques for Choriocarcinoma Research
Faraaz Rattani & Ashwin Menachery
Lay Summary:
We worked on labeling different parts of a cell that may indicate a dangerous type of cancer related to pregnancy. These "annotations" help different models to be able to detect if a person has this type of cancer or other abnormalties.
Abstract:
Choriocarcinoma is a rare and aggressive form of placenta cancer that presents significant challenges for early detection and diagnosis due to its ability to mimic common pregnancy-related issues. Accurate identification of chorionic villi, which are critical indicators of choriocarcinoma, is essential for effective diagnosis, but manual analysis of these tissues is both time-consuming and requires a high level of expertise. In this study, we aimed to develop a comprehensive and well-annotated dataset of chorionic villi from high-resolution whole-slide images (WSIs) of products of conception (POC) tissue samples. Utilizing a hybrid approach that combined the Segment Anything Model (SAM), an AI-based segmentation tool, with manual verification and corrections, we successfully annotated approximately 4,000 villi. The annotation process revealed challenges related to the irregular and varied shapes of villi, which often required manual intervention despite the assistance of SAM. The resulting dataset offers a valuable resource for future research, particularly in the development of AI-driven diagnostic tools that can enhance the accuracy and efficiency of choriocarcinoma detection. This study highlights the need for further refinement of automated segmentation tools and establishes a foundation for ongoing advancements in the field of placental pathology.
Q&A:
Bios: Faraaz Rattani,Ashwin Menachery
Program Track: Advanced Research
GitHub Username:
faraazrattani -Faraaz Rattani
ashwinmenachery -Ashwin Menachery
What was your favorite seminar? Why?
My favorite seminar was the one with Jason Wei because I also want to work at open AI and I was interested by his work. I was intersted by the projects that open AI is working on and made me really invested in this seminar. -Faraaz Rattani
My favorite was the seminar presented by Jason Wei. It was so cool to hear from someone who works at openAI since they do such fascinating work. It also seems like something I could do as a career. -Ashwin Menachery
If you were to summarize your summer internship experience in one sentence, what would it be?
I enjoyed my expreince interning at darmouth, being able to learn various concepts related to pathology and machine learning. -Faraaz Rattani
My summer internship experience was incredibly fun, and I gained a lot of valuable knowledge and experience. -Ashwin Menachery